There is a finished side to plywood like oak, maple and others and maybe I am just weird, but I do factor grain direction if I am going to stain. Painting or using a lower quality plywood, MDF or melamine, dont focus on grain direction that much. But to jaimeM's question, I personally think breaking down a 4x8 sheet on saw horses or the ground is better. Assuming he is using a TS55 or TS75, he should get glue ready joints, provided his setup is square. If he needs angled cuts maybe using MFT would work better. In the end it all comes down to personal choice and what works best for their work process.