I see lots of posts on how to join face frames to cabinets with the Domino but can't find anything about constructing the face frames themselves.  Bear with me because I am a total noob. 

I have rails and stiles that are 25 mm deep by 50 mm wide.  I can centre the tenon in the stile using the saddle fence - that puts the centre of that mortise 25 mm from the edge.  The alignment pins on the base of the Domino will put the centre of the mortise in the rail 37 mm from the edge.  I would like to make both mortises at the minimal width so the tenons can draw the parts into alignment.  Is there a way to make the centre of the mortise in the rail 25 mm from the edge?  I know I could just draw a pencil line 25mm from the edge of the rail and use the line scribed in the clear plastic reference scale but wonder if that would be accurate enough.

Any help would be most appreciated.

Awesome!   Thanks so much!

The last face frame (oak) construction I did (for own use) before I bought myself a Domino, I used an invisible nailing kit (nails countersunk under a raised shaving of wood). And, while I didn't use any type of attachment between rails and stiles, it's held up well. But in saying that, I've always been apprenhensive about the wood suffering expansion and contraction problems producing gaps.

Now, I'd want to use the Domino to attach the rails and stiles if only to add a little extra support  protection against possible gaps appearing.