A side note for hobbyists or non-high end, pocket holes can work GREAT when you are working with built-in cabinets. Just this week, restoring 30-40 or 50 year old cabinets, adding a spot for a dishwasher in one of our rentals and altering the cabinets, I was able to put in a new stile to make the face frame look right, and able to throw in a couple pocket holes in the top rail that I couldn't take off (staining the cabinets so we needed to do as little obtrusive stuff as possible) and one in the rail supporting the drawers. Pocket holes in the new side panel which attach to the face frame, dadoed the slots for the mid and bottom shelves, removed the quarter to half inch of warpage on the mid shelf, and got a very sexy tight fit (Eep, can I say that here? It would be good to go on public television I think...). I couldn't get the pocket hole kreg to fit on the bottom rail so I just countersunk a couple holes, drove in some 3" construction screws with glue and used some hole plug cutters on the matching wood for the new stile and except for a VERY small difference in coloring from the new and 40 year old wood, the patch is going to barely be noticeable with the gel stain. Much faster to put together where clamps would have been very problematic. Again- this is a rental but they work in this situation. Also had a long spanning overhead cabinet where the center stile was separating from the bottom rail (they used standard glue and dowels to assemble the face frame) and I was able to clean the joint, re-glue it, prop a wedge under it over the counter, and again, a couple of pocket holes to the back to help add the screws for the downward forces. That and the new glue should help it last a long enough time until the cabinets are ready to be replaced. Again- it's a spot you won't ever see, and its quick and efficient when you can't exactly put in a new dowel or clamp the joint.
That said- I can't WAIT to get a Domino for some new cabinet and other project work... that will be fun [big grin]. I think the biscuit while a good idea just falls short with the advent of the Domino. It's just been around longer.