I write this as an amateur woodworker with a different set of targets than professionals and likely most other amateurs. It is just an opinion.
I purchased a Domino 500 several years ago to make loose tenon joinery for door frames in a kitchen build. The first thing I learned was that the size of the dominos was limiting insofar as their width was not ideal. I am used to traditional M&T joinery, where one makes the width of the tenon to suit the circumstance. The Domino in the kitchen build left me with either the correct thickness (1/3 rule) and too narrow for sufficient rigidity, or (as I ended up) using thicker dominos for increased rigidity and less twisting. The Domino went onto a shelf for some years.
In recent years I have resurrected the Domino as a mortiser. It is pretty good for making mortises of any width. I even came up with a jig to accurately measure and position a mortise width of choice. I make my own custom dominos from scraps of the same wood.
I've come to like this machine - recognise here that I come from 30 years as a traditional, hand tool-orientated amateur woodworker. Time saving is not a big factor for me. Yes, I do have limited time in the workshop, but building with a eye on wood movement, aesthetics and traditional, time-proven joinery is far more important. And here in lies an issue ...
A question you have to ask yourself is whether you design around the joinery envelope of the machine, or whether you design joinery to match your need. The Domino (and biscuit joiner), if using the supplied, factory-made joiners (domino and biscuits) will limit your designs.
You cannot simply double up dominos for added strength since the pieces you use then need to accomodate dimensionally. I see furniture produced this way using styles wider than I would prefer.
What happened to haunched shoulders? These frame-and-panel doors ...
... use mitred haunched tenons ...
What about case construction? Butt joints and mitres can look good, but what about dovetailing in various styles? Are you going to take the easy way out?
Mitred and rounded through dovetails below ...
There is an important place for loose tenon joinery. One big advantage is that you can select the wood grain direction for your loose tenons. This was driven home to me when building these chairs - the first set I build was discarded as the tenons had too much runout.
Slender and yet strong ...
My intention is writing this is not to be critical of the Domino, which I think is a great tool. It is to raise awareness that one needs to bring a tool to your work, rather than the work to the tool. Consider whether you are limiting your efforts this way.
Regards from Perth
Derek