The skewed question was one thing on my mind: my original pin fence needs the fence locked upright before adjusting and locking the height or it is sometimes slightly skewed. That's not your issue, but I thought I'd mention it in case you want to experiment.
Something I used to do when I first got the Domino is screw up reference surfaces; it's probably why I babble about that too much in videos.
Grab your MDF and try making some joints. The fence is always on the "show" side; show sides should end up flush. If you draw a quick pencil line from one board to the other over a joint, the pencil marks indicate the show sides that will be flush. What I did on a storage cabinet when I first got the Domino is use the pins and cross-stops to march across the side of a board. Problem was I assumed since they were properly spaced from one edge, they were correct. I needed them spaced from that edge and referenced from the correct show side. That cabinet became about 15mm narrower than planned
You don't need to use pencil marks, but using that description to make is clearer how the reference surfaces are chosen.
For practicing on 18mm (3/4") MDF, set your Domino's thickness gauge to 20mm; that will place the mortise off-center. Now, if you get the reference surfaces mixed up, you'll get a pronounced step. I do that intentionally so while doing a glue-up, it is really obvious if I flipped when I shouldda flopped a board.
It does take practice, but you should be getting better joints than that pretty quickly. Oh, common problem I also had: board is on the bench and I try to mortise into the side... except the height setting is such that the bottom of the Domino needs to go further down than the bench surface (make sense?). Clamp the board so the end you are mortising is off the bench. Let's not talk about how many times I did that.