Chris, 10minutes in a clamp is all I need for some good grab, then I just move the clamps down the side enough to clear the Domi base. And with the Domi tenons, I use the 5mm bit at its maximum 20mm depth to plunge the mortise, then with the tenons, I scribe a line 2mm under that depth (18mm) then from the scribe line I round over the lower half to fit the mortise. When I tap them in, I always clamp the side with an F-Clamp to stop the drawer side splitting, and then when the tenon is fully inserted, the top 2mm that is square will press its self into the round side and square it all up.
Below is a drawer ready to be assembled. Note for the astute observer, yes the grain is going the wrong way (above pic) ;D but I figure with so many laminations movement will be minimal and 2.5mm both sides of the rebate have been left and a little foam just to stop the rattle.