One of the considerations is the surface volume you do - if it's a lot, I think the area sanded to cost of paper ratio would be slanted in favour of the 6".
Surely you could try either for 30 days and determine if the 5" feels too small or the 6" felt too big?? Or is that something only Festool USA offer?
I've toyed with the idea of getting a Mirka Ceros sander for quite a while ... but I've made up my mind ...
I currently have RO 150, RO 90, ETS150/5 then Rupes delta, Rupes 6" orbital, Bosch 75mm belt and a Makita 1/3 sheet, The final stable is going to be Festool only, growing by (in this order) DTS400, ETS150/3, RS2E then either the BS75E or BS105E.
Plugit was another factor, easy hose connection, etc and local service/support for a Mirla Ceros here in Oz is a big unknown. Pad selection is also a factor ... But, back on 5" v's 6" I'm choosing ETS15/3 over the finer orbit ETS125 to eliminate a paper size, only worrying about 6" paper across my RO 150, ETS150/5 and soon to be ETS150/3.
I'm not just trying to wave the Festool flag here - I wanted to share my thinking. Worth noting is that I don't have anywhere local that I can go and try the Mirka Ceros - this was significant in my decision process.
Kev.