The only ‘defect’ which has destroyed three of my numerous Systainers is that the plastic doesn’t like strong solvents (who would have thought it, huh?).
I had set up a stack of three - with various adhesives in the top one. A litre can of toluene-based impact adhesive was lying on its side and emptied its contents when the lid unfortunately came off. The glue dissolved a canyon-sized hole in the bottom, then through the lid of the one underneath, then through the bottom, then through the lid of the next one, then through the bottom and out on the floor.
It reminded me of the famous ‘molecular acid’ scene in the first Alien movie.