I do not have a vice, but I have an MFT and Vac Sys and feel qualified enough to say no. I like the Vac Sys for some operations like sanding, because it is very easy to flip things, and there is no futzing around with the ratchet clamps or clamping elements in the right holes. However, if I could only have one, I would pick the clamping elements/ratchet clamps. The vac sys can't hold everything. It can be too small, too big (so there is too much leverage), have holes in the middle, not be flat. Other clamping solutions will handle those difficulties - possibly with some annoyance, but in my experience the vac sys will not [or the work arounds would be harder than just using clamps in the first place].